Journal article
Association between multiple sclerosis risk-associated SNPs and relapse and disability - A prospective cohort study
R Lin, BV Taylor, S Simpson, J Charlesworth, AL Ponsonby, F Pittas, T Dwyer, I Van Der Mei
Multiple Sclerosis Journal | Published : 2014
Abstract
Background: The modulating effects of the multiple sclerosis (MS) risk-associated single-nucleotide polymorphisms (SNPs) on MS clinical course are not well established. Objectives: The objective of this paper is to investigate whether known MS risk-associated SNPs were associated with clinical course, and whether these SNPs modified the 25(OH)D-relapse association. Methods: Using a prospective cohort of 141 participants with relapsing-remitting MS and genotype data followed between 2002 and 2005, genotype-vitamin D interactions and the genetic predictors of relapse were assessed using survival analysis, and genetic predictors of 25(OH)D and disability progression were evaluated by multilevel..
View full abstractGrants
Awarded by Australian Research Council
Funding Acknowledgements
This work was supported by the National Health and Medical Research Council (NHMRC) of Australia (Project 333105 and 605511). SSJ is supported by a postdoctoral fellowship from MS Research Australia. IvdM is supported by an Australian Research Council Future Fellowship. A-LP is supported by an NHMRC senior research fellowship.